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Blood metabolites associated with coffee consumption may affect kidney disease risk
Food and beverages may have important effects on kidney health, but the potential biological mechanisms involved are often unclear. New research in the US identifies several metabolites in the blood whose levels are altered by coffee consumption and may affect the risk of developing chronic kidney disease (CKD).
Researchers at the Johns Hopkins Bloomberg School of Public Health have identified that levels of 3 coffee-related metabolites were significantly associated with individuals’ risk of developing chronic kidney disease, namely- glycochenodeoxycholate, O-methylcatechol sulfate, and 3-methyl catechol sulfate.
Glycochenodeoxycholate, a lipid involved in primary bile acid metabolism, may contribute to potentially beneficial effects of coffee consumption on kidney health. O-methylcatechol sulfate and 3-methyl catechol sulfate, which are involved in metabolism of the preservative benzoate, may represent harmful aspects of coffee on the kidneys.
With more research on the metabolic underpinnings of the coffee-kidney relationship, these metabolites may point to processes that are relevant for preventing kidney disease through dietary modifications.